Much better known for his love for the ladies, McSteamy also had a soft spot for one special guy: Derek Shepherd. Through punches and pummeling,…

1. Mark Sloan’s unforgettable introduction at Seattle Grace

Mark Sloan made a dramatic entrance when he arrived at Seattle Grace Hospital looking for Derek Shepherd. His appearance instantly stirred tension because of his complicated history with Derek and Addison Montgomery.

The reveal that Mark had been involved with Addison shocked both Derek and viewers, setting the stage for one of the show’s earliest and most dramatic rivalries.

Has speaking in code ever been this sultry? McSteamy's former lover Callie said she wanted sorbet...but she wasn't referring to a fruity frozen treat. The…

2. The moment Mark earned the nickname “McSteamy”

Not long after joining the hospital, Mark’s reputation began spreading among the interns.

During a now-iconic scene, the interns walk in on Mark stepping out of the shower wrapped in nothing but a towel. Completely unfazed, Mark confidently introduces himself — and the moment earns him the nickname “McSteamy.”

It quickly became one of the most recognizable character nicknames in the entire series.

Before Sloan's time was up at Seattle Grace, his character had come full circle. Watching him fully embrace fatherhood, co-parenting Sofia with Callie and Arizona,…

3. Mark and Addison’s complicated reunion

Mark’s arrival also reopened old wounds with Addison.

The two share several tense and emotional moments as they try to figure out what their relationship means after the betrayal that ended Addison’s marriage with Derek.

Their chemistry made these scenes both dramatic and emotionally charged.

No well-rounded heartthrob is complete without a sense of humor. So, when the elevator doors opened on McSteamy back in season 4, revealing McDreamy stuck…

4. The friendship that rebuilt between Mark and Derek

Despite their painful past, Mark and Derek eventually rebuilt their friendship.

Over time, their rivalry evolved into a brother-like relationship filled with humor, teasing, and mutual support. Their scenes together became some of the show’s most entertaining moments.

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5. Mark and Callie’s unexpected bond

Mark developed one of his most surprising relationships with orthopedic surgeon Callie Torres.

What began as a casual connection eventually grew into a genuine friendship built on trust and loyalty. Their dynamic added both humor and emotional depth to the show.

Despite being in an off-again phase, the emotional undercurrent between McSteamy and Lexie still ran deep during the stunning season 6 finale. When a devastated…

6. The beginning of Mark and Lexie’s romance

One of Mark’s most beloved storylines began when he formed a romantic connection with Lexie Grey.

Despite their age difference, the two shared undeniable chemistry. Their relationship quickly became one of the most talked-about romances on the show.

Sent into the throes of agony by an on-call quickie? Classic McSteamy! Bent but not broken, the doc's appendage was back in full service by…

7. Mark realizing his feelings for Lexie

As their relationship evolved, Mark eventually realized that his connection with Lexie meant far more to him than he originally expected.

These emotional scenes revealed a more vulnerable side of Mark, showing that beneath his confident personality was someone capable of deep love.

He came in with a bang — to his face. We'd first heard about Mark Sloan in the season 2 opener when Derek told Meredith…

8. Mark discovering he has a daughter

One of the biggest surprises in Mark’s life came when he discovered he had a daughter, Sloan Riley.

The storyline forced Mark to confront responsibilities he had never expected. It also showed a new side of the character as he struggled to adapt to becoming a father.

Was there a dry eye among Grey's watchers as McSteamy said his last goodbye to Lexie? No. Refusing to let his future with Lexie be…

9. Mark’s emotional growth as a character

Throughout his time on Grey’s Anatomy, Mark evolved from a charming but reckless surgeon into someone more emotionally mature.

His relationships with friends, lovers, and family helped transform him into a far more complex character than viewers first met.

This season 3 moment may not technically have been when Sloan took on the McSteamy moniker, but there was no doubt after seeing him emerge,…

10. Mark Sloan’s lasting legacy on the show

Even after his departure from the series, Mark Sloan remains one of the most beloved characters in Grey’s Anatomy history.

Eric Dane’s performance turned McSteamy into a fan favorite whose moments — both romantic and emotional — continue to be remembered by longtime viewers of the show.